Message from the President: Standard Practice?


Complications and Quality Improvement for High-Risk Surgery


Maximizing Outcomes Studies


Measurement in the ICU


CEO Column: The Impact of Industry on Critical Care


Strategies to Minimize Antimicrobial Resistance in the ICU: The Role of the Pharmacist


Challenges to Measuring Outcomes in PICU Patients


Measuring Resources Using Weighted Hospital Days


Square One, Revisited: The Role of Outcome Research in Critical Care Nursing


Does Anemia Treatment Improve Outcomes in ICU Patients?




Message from the President: Standard Practice?

1. The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 2000;342:1301-1308


2. Shapiro BA, Warren J, Egol AB, et al: Practice parameters for intravenous analgesia and sedation for adult patients in the intensive care unit: An executive summary. Crit Care Med 1995; 23: 1596-1600


3. Jacobi J, Fraser GL, Coursin DB, Riker RR, Fontaine D, Wittbrodt ET, Chalfin DB, Masica MF, Bjerke HS, Coplin WM, Crippen DW, Fuchs BD, Kelleher RM, Marik PE, Nasraway SA Jr, Murray MJ, Peruzzi WT, Lumb PD; Task Force of the American College of Critical Care Medicine (ACCM) of the Society of Critical Care Medicine (SCCM), American Society of Health-System Pharmacists (ASHP), American College of Chest Physicians. Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult. Crit. Care Med. 2002; 30:119-41


4. Arensberg D, Baker A, Friedman L, Greene HL, et al. Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial. N Engl J Med. 1991;324:781-8


Complications and Quality Improvement for    High-Risk Surgery

1. Institute of Medicine, To Err is Human: Building a Safer Health System. Washington: National Academy Press, 1998.


2. Institute of Medicine, Crossing the Quality Chasm: A New Health System for the Twenty-first Century. Washington: National Academy Press, 2001.


3. Dimick JB, Pronovost PJ, Cowan JA, Lipsett PA. Related Articles, Links Complications and costs after high-risk surgery: where should we focus quality improvement initiatives? J Am Coll Surg 2003;196:671-678.


Maximizing Outcomes Studies
1. Pronovost PJ, et al. Physician staffing patterns and clinical outcomes in critically ill patients: a systematic review. JAMA. 2002;288:2151-2162.


2. Combes, A. et al. Morbidity, mortality, and quality-of-life outcomes of patients requiring > 14 days of mechanical ventilation. Crit Care Med. 2003;31:1373-1381.


3. Donabedian, A. Evaluating the quality of medical care. Milbank Mem Fund Q. 1966;44:Suppl.166-206.


4. Wu AW. Principles of outcomes assessment. In: Plum F, Bennett JC, editors. Cecil Textbook of Medicine. 21 st ed. Philadelphia, W.B. Saunders Company, 2000.


5. Kohn LT, Corrigan JM, Donaldson, MS, eds. To err is human: building a safer health system. Washington, DC: National Academy Press, 2000.


6. Institute of Medicine. Crossing the quality chasm: a new health system for the 21 st century. Washington, DC: National Academy Press, 2001


Measurement in the ICU

1. Nelson, LD. Data, data everywhere. Crit Care Med, 1997; 25: 1265.


2. Weissman C: Can hospital discharge diagnoses be used for intensive care unit administrative and quality management functions? Crit Care Med, 1997; 25:1320-1323.


3. Buchman TG: Critical care: On target. Crit Care Med, 2003; 31: 1003-1005.


4. Intensivist Programs - Elevating the standard of critical care. Clinical Advisory Board, Washington, D.C., 2001.


5. Champion HR, Copes WS, Sacco WJ, et al. The Major Trauma Outcome Study, Establishing national norms for trauma care. J Trauma, 1990; 30: 1356-1365.


CEO Column: The Impact of Industry on Critical Care

1. Rosenthal, M.B., Berndt, E.R., Donohue, J.M., et al., "Promotion of Prescription Drugs to Consumers," New England Journal of Medicine , 346(7), 2002, pages 498-505.


2. Kaiser Family Foundation report, Trends in Direct-to Consumer Advertising of Prescription Drugs , February 2002.


Strategies to Minimize Antimicrobial Resistance in the ICU

1. Gums JG. Assessing the impact of antimicrobial resistance. Am J Health Syst Pharm 2002; 59 (suppl): S4-S6.


2. Neuhauser MM, Weinstein RA, Rydman R et al. Antibiotic resistance among gram-negative bacilli in US intensive care units: implications for fluoroquinolone use. JAMA 2003; 289:885-888.


3. Ibrahim KH, Gunderson B, Rotschafer JC. Intensive care unit antimicrobial resistance and the role of the pharmacist. Crit Care Med 2001; 29 (suppl 4): S10-S12.


4. Papadopoulos J, Rebuck JA, Lober C et al. The critical care practitioner: an essential intensive care practitioner. Pharmacotherapy 2002; 22: 1484-8.


5. Gross R, Morgan AS, Kinky DE et al. Impact of a hospital-based antimicrobial management program on clinical and economic outcomes. Clin Infect Did 2001; 33:289-95.


6. Hyatt JM, McKinnon PS, Zimmer GS et al. The importance of pharmacokinetic/pharmacodynamic surrogate markers to outcome: focus on antimicrobial agents.   Clin Pharmacokin 1995; 28: 143-60.


7. Raymond DP, Pelletier SJ, Crabtree TD et al. Impact of a rotating empiric antibiotic schedule on infectious mortality in an intensive care unit. Crit Care Med 2001; 29:1101-1108.


8. Kollef MH, Ward S, Sherman G et al. Inadequate treatment of nosocomial infections is associated with certain empiric antibiotic choices. Crit Care Med 2000;28:3456-3464.


9. Luna CM, Blanzaco D, Niederman MS et al. Resolution of ventilator-associated pneumonia: Prospective evaluation of the clinical pulmonary infection score as an early clinical predictor of outcome. Crit Care Med 2003: 31: 676-682.


10. Chastre J et al.   Presented at the American Thoracic Society Meeting, 2003.


Challenges to Measuring Outcomes in PICU Patients

1. Fiser DH. Outcome evaluations as measures of quality in pediatric intensive care. Pediatric Clinics of North America 1994; 41:1423-1438.


2. Fiser DH. Can we assess quality of life for survivors of pediatric intensive care? Pediatric Critical Care Medicine 2002; 3:84-85.


3. Lollar DJ, Simeonsson RJ, Nanda U. Measures of outcome for children and youth. Arch Phys Med Rehabil 2000; 81:S46-S52.


4. Gormley ME, Krach LE. Pediatric functional assessment. Rehab Management 1997:32-35, 103.


5. Fiser DH. Assessing the outcome of pediatric intensive care. J Pediatr 1992; 121:68-74.


6. Osher TW. Outcomes and accountability from a family perspective. Journal of Behavioral Health Services & Research 1998; 25:230-232.


7. Pollack MM, Patel KM, Ruttimann UE. PRISM III: an updated Pediatric Risk of Mortality score. Crit Care Med 1996; 24:743-52.


8. Tilford JM, Roberson PK, Lensing S, Fiser DH. Differences in pediatric ICU mortality risk over time. Crit Care Med 1998; 26:1737-43.


9. Fiser DH, Tilford JM, Roberson PK. Relationship of illness severity and length of stay to functional outcomes in the pediatric intensive care unit: a multi-institutional study. Crit Care Med 2000; 28:1173-9.


10. Fiser DH, Long N, Roberson PK, Hefley G, Zolten K, Brodie-Fowler M. Relationship of pediatric overall performance category and pediatric cerebral performance category scores at pediatric intensive care unit discharge with outcome measures collected at hospital discharge and 1- and 6-month follow-up assessments. Crit Care Med 2000; 28:2616-20.


Measuring Resources Using Weighted Hospital Days

1. Rapoport J, Teres D, Lemeshow S et al: A Method for Assessing the Clinical Performance and Cost-Effectiveness of Intensive Care Units: A multicenter inception cohort study. Crit Care Med 1994;22:1385-1391


2. Rapoport J, Teres D, Zhao Y et al: Length of Stay Data as a Guide to Hospital Economic Performance for ICU Patients. Med Care 2003;41:386-397


3. Higgins TL, McGee WT, Steingrub JS, et al. Early indications of prolonged intensive care unit stay: Impact of illness severity, physician staffing, and pre-intensive care unit length of stay. Crit Care Med , 2003, Vol. 31, No 1, 45-51


Square One, Revisited: The Role of Outcome Research in Critical Care Nursing (Page 14)

1.Coyle YM. Developing theoretical constructs for outcomes research. American Journal of the Medical Sciences. 319(4):245-9, 2000 Apr


2. Kleinpell-Nowell R. Strategies for assessing outcomes in the elderly in acute care. AACN Clinical Issues. 11(3):442-52, 2000 Aug.


3.Gerszten PC. Outcomes research . : Neurosurgery 43(5):1146-56, 1998 Nov


4. Mark BA. Salyer J. Methodological issues in treatment effectiveness and outcomes research. Outcomes Management for Nursing Practice. 3(1):12-8; quiz 18-9, 1999 Jan-Mar


5.Gerszten PC. Outcomes research : Neurosurgery. 43(5):1146-56, 1998 Nov


6.Houston S. Getting started in outcomes research . AACN Clinical Issues. 7(1):146-52, 1996 Feb.


Does Anemia Treatment Improve Outcomes in ICU Patients? (Page 16)

1. Goodnough LT, Dubois R, Nissenson NA: Anemia: not just an innocent bystander?   Arch Int Med 2003, in press 6/23/03.


2. Littlewood TJ, Bajetta E, Nortier JWR, et al: Effects of epoetin alfa on hematologic parameters and quality of life in cancer patients receiving nonplatinum chemotherapy: results of a randomized double-blind, placebo-controlled trial. J Clin Oncology 2001 ; 19:2865-2874.


3. Hébert PC, Wells G, Tweeddale M, et al: Does transfusion practice affect mortality in critically ill patients? Am J Respir Crit Care Med 1997 ; 155:1618-1623.


4. Aldemir M, Özen S, Kara IH, Sir A, Baç B: Predisposing factors for delirium in the surgical intensive care unit. Crit Care 2001 ; 5:265-270.


5. Rodriguez RM, Corwin HL, Gettinger A, Corwin MJ, Gubler D, Pearl RG: Nutritional deficiencies and blunted erythropoietin response as causes of the anemia of critical illness. J Crit Care   2001 ; 16(1): 36-41.


6. von Ahsen N, Müller C, Serke S, Frei U, Eckardt KU: Important role of nondiagnostic blood loss and blunted erythropoietic response in the anemia of medical intensive care patients. Crit Care Med 1999 ; 27(12): 2630-2639.


7. Hébert P, Wells G, Blajchman MA, et al: A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. N Engl J Med 1999 ; 340: 409-417.


8. Hébert PC, Yetisir E, Martin C, Blajchman MA, Wells G, Marshall J, et al: Is a low transfusion threshold safe in critically ill patients with cardiovascular diseases? Crit Care Med   2001 ; 29(2): 227-234.


9. Taylor RW, Manganaro L, O'Brien J, Trottier SJ, Parkar N, Veremakis C. Impact of allogenic packed red blood cell transfusion on nosocomial infection rates in the critically ill patient. Crit Care Med 2002 ; 30(10): 2249-2254.


10. Vincent JL, Baron JF, Reinhart K, Gattinoni L, Thijs L, Webb A, et al: Anemia  and blood transfusion in critically ill patients.   JAMA 2002 ; 288(12): 1499-1507.


11. Corwin HL, Gettinger A, Rodriguez RM, et al: Efficacy of recombinant human erythropoietin in the critically ill patient: a randomized double blind placebo controlled trial. Crit Care Med 1999 ; 27: 2346-2350.


12. Corwin HL, Gettinger A, Pearl RG, Fink MP, Levy MM, Shapiro MJ, et al: Efficacy of recombinant human erythropoietin in critically ill patients: a randomized controlled trial. JAMA 2002 ; 288(22): 2827-2835.


13. Carson JL: Should patients in intensive care units receive erythropoietin? JAMA 2002 ; 288(22): 2884-2886.

August 2003
- August 2003
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