Pharmaceutical Dilemmas in the ICU Cancer Patient
Todd Canada, PharmD, BCNSP
The University of Texas M. D. Anderson Center
Houston, Texas, USA


1. Dorffler-Melly J, de Jonge E, de Pont A, et al. Bioavailability of subcutaneous low-molecular-weight heparin to patients on vasopressors. Lancet 2002; 359: 849-50.


2. Kress JP, Christenson J, Pohlman AS, Linkin DR, Hall JB. Outcomes of critically ill cancer patients in a university hospital setting. Am J Respir Crit Care Med 1999; 160: 1957-61.


3. Davidson MB, Thakkar S, Hix JK, Bhandarkar ND, Wong A, Schreiber MJ. Pathophysiology, clinical consequences, and treatment of tumor lysis syndrome. Am J Med 2004; 116: 546-54.


PICU Care of Children with Cancer

Alan Fields
The Children’s Cancer Hospital at the University of Texas M. D. Anderson Center
Houston, Texas, USA

Rodrigo Mejia, MD
The Children’s Cancer Hospital at the University of Texas M. D. Anderson Center
Houston, Texas, USA


1. Butt W, Barker G, Walker C, Gillis J, Kilham H, Stevens M. Outcome of children with hematologic malignancy who are admitted to an intensive care unit. Crit Care Med. 1988; 16:761-4.


2. Diaz MA, Vicent MG, Prudencio M, et al. Predicting factors for admission to an intensive care unit and clinical outcome in pediatric patients receiving hematopoietic stem cell transplantation. Haematologica. 2002; 87:292-8


3. Schneider DT, Lemburg P, Sprock I, Heying R, Gobel U, Nurnberger W. Introduction of the oncological pediatric risk of mortality score (O-PRISM) for ICU support following stem cell transplantation in children. Bone Marrow Transplant. 2000; 25:1079-86.


4. Hallahan AR, Shaw PJ, Rowell G, O'Connell A, Schell D, Gillis J. Improved outcomes of children with malignancy admitted to a pediatric intensive care unit. Crit Care Med. 2000; 28:3718-21.


5. Kutko MC, Calarco MP, Flaherty MB, et al. Mortality rates in pediatric septic shock with and without multiple organ system failure. Pediatr Crit Care Med. 2003; 4:333-7.


6. Pollack MM, Ruttimann UE, Getson PR. Pediatric risk of mortality (PRISM) score. Crit Care Med. 1988; 16:1110-6.


7. Rossi R, Shemie SD, Calderwood S. Prognosis of pediatric bone marrow transplant recipients requiring mechanical ventilation. Crit Care Med. 1999; 27:1181-6


8. Jacobe SJ, Hassan A, Veys P, Mok Q. Outcome of children requiring admission to an intensive care unit after bone marrow transplantation. Crit Care Med. 2003; 31:1299-305.


9. Wilkinson JD, Pollack MM, Ruttimann UE, Glass NL, Yeh TS. Outcome of pediatric patients with multiple organ system failure. Crit Care Med. 1986; 14:271-4.


10. Hagen SA, Craig DM, Martin PL, et al. Mechanically ventilated pediatric stem cell transplant recipients: effect of cord blood transplant and organ dysfunction on outcome. Pediatr Crit Care Med. 2003; 4:206-13.


11. Todd K, Wiley F, Landaw E, et al. Survival outcome among 54 intubated pediatric bone marrow transplant patients. Crit Care Med. 1994; 22:171-6


12. Keenan HT, Bratton SL, Martin LD, Crawford SW, Weiss NS. Outcome of children who require mechanical ventilatory support after bone marrow transplantation. Crit Care Med. 2000; 28:830-5.


13. Bojko T, Notterman DA, Greenwald BM, De Bruin WJ, Magid MS, Godwin T. Acute hypoxemic respiratory failure in children following bone marrow transplantation: an outcome and pathologic study. Crit Care Med. 1995; 23:755-9.


14. Diaz de Heredia C, Moreno A, Olive T, Iglesias J, Ortega JJ. Role of the intensive care unit in children undergoing bone marrow transplantation with life-threatening complications. Bone Marrow Transplant. 1999; 24:163-8.

 

Nutrition Management of the Hematopoietic Stem Cell Transplant Recipient in the ICU
Sara Bergerson, RD
Clinical Center,
National Institutes of Health
Bethesda, Maryland, USA

Brad Moriyama, PharmD
Clinical Center,
National Institutes of Health
Bethesda, Maryland, USA


1. Lenssen P, Bruemmer B, Aker SN, et al. Nutrient support in hematopoietic cell transplantation. JPEN 2001; 25(4):219-28.


2. Wong PW, Enriquez A, Barrera R. Nutritional support in critically ill patients with cancer. Crit Care Clin 2001; 17(3):743-67.


3. Chan S, McCowen KC, Blackburn GL. Nutrition management in the ICU. Chest 1999; 115(5 Suppl):145S-148S.


4. Taveroff A, McArdle AH, Rybka WB. Reducing parenteral energy and protein intake improves metabolic homeostasis after bone marrow transplantation. Am J Clin Nutr 1991; 54(6):1087-92.


5. Zaloga GP, Roberts P. Permissive underfeeding. New Horiz 1994; 2(2):257-63.


6. Monson P, Mehta RL. Nutritional considerations in continuous renal replacement therapies. Semin Dialysis. 1996; 9:152-160.


7. Weisdorf SA, Lysne J, Wind D, et al. Positive effect of prophylactic total parenteral nutrition on long-term outcome of bone marrow transplantation. Transplantation 1987; 43(6):833-8.


8. Guidelines for the use of parenteral and enteral nutrition in adult and pediatric patients. JPEN 2002; 26(1 Suppl):S83-4.


9. Spain DA. When is the seriously ill patient ready to be fed? JPEN 2002; 26(6 Suppl):S62-8.


10. Gauvreau JM, Lenssen P, Cheney CL, et al. Nutritional management of patients with intestinal graft-versus-host disease. J Am Diet Assoc 1981; 79(6):673-7.


Critical Care of Cancer Patients

Brenda K. Shelton, MS, RN, CCRN, ACCN
The Sidney Kimmel Comprehensive Center
John Hopkins
Baltimore, Maryland, USA


1. National Cancer Institute. Surveillance, Epidemiology, and End Results Program, 1975-2001, Division of Cancer Control and Population Sciences, National Cancer Institute, 2004


2. Shelton, B.K. (1994). Cancer critical care: past, present and future, Seminars in Oncology Nursing, 10(3): 146-155.


3. Azoulay, E., Moreau, D., Alberti, C., Leleu, G., Adrie, C., Barboteu, M., Cottu, P., Levy, V., Le Gall, J.R., Schlemmer, B. (2000). Predictors of chort-term mortality in critically ill patients with solid malignancies, Intensive Care Medicine, 26: 1817- 1823.


4. Benoit, D.D., Vandewoulde, K.H., Decruyenaere, J.M., Hoste, E.A., Colardyn, F.A. (2003). Outcome and early prognostic indicators in patients with a hematologic malignancy admitted to the intensive care unit for a life-threatening complication, Critical Care Medicine, 31(1): 104-112.


5. Kongsgaard, U.E., & Meidell, N.K. (1999). Mechanical ventilation in critically ill cancer patients: outcome and utilization of resources, Supportive Care in Cancer, 7: 95-99.


6. Staudinger, T., Stoiser, B., Mullner, M., Locker, G.J., Laczika, K., Knapp, S., Burgmann, H., Wilfing, A., Kofler, J., Thalhammer, F., Frass, M. (2000). Outcome and prognostic factors in critically ill cancer patients admitted to the intensive care unit, Critical Care Medicine, 28(5): 1322-1328.


7. Kress, J.P., Christenson, J., Pohlman, A.S., Linkin, D.R., Hall, J.B. (1999). Outcomes of critically ill cancer patients in a university hospital setting, American Journal of Respiratory Critical Care Medicine, 160: 1957- 1961.


8. Gordon, A.C., Oakervee, H.E., Kaya, B., Thomas, J.M., Barnett, M.J., Rohatiner, A.Z.S., Lister, T.A., Cavenagh, J.D., Hinds, C.J. (2005). Incidence and outcome of critical illness amongst hospitalized patients with haematologivcal malignancy: a prospective observational study of ward and intensive care unit based care, Anesthesia, 60: 340-347.


9. Ghosn, M., Kanso, C., Kattan, J., Chahine, G., Tueini, E., Nasser, E., Yazbeck, P. (2002). Outcome of cancer patients admitted to the intensive care unit (ICU), Journal Medicine Libania, 50(4): 132-136.


10. Khassawneh, B.Y., White, Jr., P., Anaissie, E.J., Barlogie, B., Hiller, F.C. (2002). Outcome from mechanical ventilation after autologous peripheral blood stem cell transplantation, Chest, 121: 185-188.


11. Maschmeyer, G., Bertschat, F.L., Moesta, K.T., Hausler, E., Held, T.K., Nolte, M., Osterziel, K.J., Papstein, V., Peters, M., Reich, G., Schmutzler, M., Sezer, O., Stula, M., Wauer, H., Wortz, T., Wischnewsky, M., Hohenberger, P. (2003). Outcome analysis of 189 consecutive patients referred to the intensive care unit as emergencies during a 2-year period, European Journal of Cancer, 39: 783-792.


12. Azoulay, E., Recher, C., Alberti, C., Soufir, L., Leleu, G., Le Gall, J.R., Fermand, J.P., Schlemmer, B. (1999). Changing use of intensive care for hematological patients: the example of multiple myeloma, Intensive Care Medicine, 25: 1395- 1401.


13. Freedman, N., Hansen-Flaschen, J. (2003). Intensive care for oncology patients: short- term prognosis, UpToDate Online 13.1, www.uptodate.com, accessed May 25, 2005.


14. Tanvetyanon, T., & Leighton, J.C. (2003). Life-sustaining treatments in patients who died of chronic congestive heart failure compared with metastatic cancer, Critical Care Medicine, 31(1): 60-64.


15. Schellongowski, P., Benesch M., Lang, T., Traumuller, F., Zauner, C., Laczika, K., Locker, G.J., Frass, M., Staudinger, T. (2004). Comparison of three severity scores for critically ill cancer patients, Intensive Care Medicine, 30: 430-436.


16. Berghmans, T., Paesmans, M., Sculler, J.P. (2004). Is a specific oncological scoring system better at predicting the prognosis of cancer patients admitted for an acute medical complication in an intensive care unit than general gravity scores? Supportive Care in Cancer, 12(4): 234-239.


17. Groeger, J.S., White, Jr., P., Nierman, D.M., Glassman, J., Shi, W., Horak, D., Price, K. (1999). Outcome for cancer patients requiring mechanical ventilation, Journal of Clinical Oncology, 17(3): 991-997.


18. Price, K.J., Thall, P.F., Kish, S.K., Shannon, V.R., Andersson, B.S. (1998). Prognostic indicators for blood and marrow transplant patoents admitted to an intensive care unit, American Journal of Respiratory Critical Care Medicine, 158: 876-884.


19. Azoulay, E., Alberti, C., Bornstain, C., Leleu, G., Moreau, D., Recher, C., Chevret, S., Le Gall, J., Brochard, L., Schlemmer, B. (2001). Improved survival in cancer patients requiring mechanical ventilatory support: impact of noninvasive mechanical ventilatory support, Critical Care Medicine, 29(3):519-525.


20. Depuydt, P.O., Benoit, D.D., Vandewoude, K.H., Decruyenaere, J.M., Colardyn, F.A. (2004). Outcome in noninvasively and invasively ventilated hematologic patients with acute respiratory failure, Chest, 126(4):1299-1306.


21. Evison, J.M., Rickenbacher, P., Ritz, R., Gratwohl, A., Haberthur, Ch., Elsasser, S., Passweg, J.R. (2001). Intensive care unit admission in patients with haematological disease: incidence, outcome and prognostic factors, Swiss Medicine Weekly, 131: 681- 686.


22. Shelton, B.K. (2000). Preventing crises in the patient with cancer, Oncology Nursing Forum, 905-913.


23. Groeger, J.S., Aurora, R.N. (2001). Intensive care, mechanical ventilation, dialysis, and cardiopulmonary resuscitation. Implications for the patient with cancer, Critical Care Clinics, 17(3): 791-803, x.


24. Alkire, K., Shelton, B.K. (1994). Creating critical care oncology beds, Seminars in Oncology Nursing, 10(3): 208-221.


25. Kaplow, R. (2001). Special nursing considerations, Critical Care Clinics, 17(3): 769-789.

August 2005
- August 2005
© Copyright 2001 - 2007 Society of Critical Care Medicine