• Issues in Caring for Pediatric Patients with Head Trauma: New Guidelines Stimulating New Investigation
• The Final Diagnosis: Brain Death
• Emerging Topics in Neuroscience of Traumatic Brain Injury: Brain Metabolism 
• Respiratory Care of the Neurologic Patient
• Making a Change 
• Outcomes of ICU Patients After Neurological Injury 

2. James HE: Methodology for the control of intracranial pressure with hypertonic mannitol. Acta Neurochir 51:161-172, 1980.

3. Carney N, Chesnut R, Kochanek PM: (Foreword) Guidelines for the acute medical management of severe traumatic brain injury in infants, children and adolescents. Pediatr Crit Care Med Suppl 4:S1, 2003.

4. Tong KA, Ashwal S, Holshouser BA, Nickerson JP, Wall CJ, et al: Diffuse axonal injury in children: clinical correlation with hemorrhagic lesions. Ann Neurol 56:36-50, 2004.

5. Vavilala MS, Bowen A Lam AM, Uffman JC, Powell J, et al: Blood pressure and outcome after severe pediatric traumatic brain injury. J Trauma 55:1039-1044, 2003.

6. Vavilala MS, Lee LA, Boddu K, Visco E, Newell DW, et al: Cerebral autoregulation in pediatric traumatic brain injury. Pediatr Crit Care Med 5:257-263, 2004.

7. Cochran A, Scaife ER, Hansen KW, Downey EC: Hyperglycemia and outcomes from pediatric traumatic brain injury. J Trauma 55:1035-1038, 2003.

8. Wijdicks EFM: The Clinical Practice of Critical Care Neurology, 2^nd edition, Oxford University Press, New York, 2003.

9. Lai Y, Kochanek PM, Adelson PD, Janesko K, Ruppel RA, Clark RS: Induction of the stress response after inflicted and non-inflicted traumatic brain injury in infants and children. J Neurotrauma 21:229-237, 2004.

10. Keenan HT, Runyan DK, Marshall SW, Nocera MA, Merten DF, Sinal SH: A population-based study of inflicted traumatic brain injury in young children. JAMA 290:621-626, 2003.

11. Biswas AK, Bruce DA, Sklar FH, Bokovoy JL, Sommerauer JF: Treatment of acute traumatic brain injury in children with moderate hypothermia improves intracranial hypertension. Crit Care Med 30:2742-2751, 2002.

12. Figaji AA, Fieggen AG, Peter JC: Early decompressive craniotomy in children with severe traumatic brain injury. Childs Nerv Syst 19:666-673, 2003.

13. Hejazi N, Witzmann A, Fae P: Unilateral decompressive craniectomy for children with severe brain injury. Report of seven cases and review of the relevant literature. Eur J Pediatr 161:99-104, 2002.

14. Messing-Junger AM, Marzog J, Wobker G, Sabel M, Bock WJ: Decompressive craniectomy in severe brain injury. Zentralbl Neurochir 64:171-177, 2003.

15. Ruf B, Heckmann M, Schroth I, Hügens-Penzel M, Reiss I, et al: Early decompressive craniectomy and duraplasty for refractory intracranial hypertension in children: results of a pilot study. Critical Care 7:R133-R138, 2003 (DOI 10.1186/cc2361 ) http://ccforum.com/content/7/6/R133 

16. Taylor A, Butt W, Rosenfeld J, Shann F, Ditchfield M, et al: A randomized trial of very early decompressive craniectomy in children with traumatic brain injury and sustained intracranial hypertension. Childs Nerv Syst 17:154-162, 2001.

17. Shore P, Thomas NJ, Clark RSB, Adelson PD, Wisniewski SR, et al: Continuous vs. intermittent cerebrospinal fluid drainage after severe traumatic brain injury in children: effect on biochemical markers. J Neurotrauma 21:1113-1122, 2004.

The Final Diagnosis: Brain Death

1. The United Network for Organ Sharing (UNOS) -- A National Conference on Donation After Cardiac Death http://www.unos.org

2. Iserson, Kenneth V: Death to Dust: What Happens to Dead Bodies? TV CSON: Galen Press, Ltd., 1994, pp. 11-50.

3. Younger, Stuart J. The Definition of Death Contemporary Controversies. Baltimore: The Johns Hopkins University Press, 1999, pp 34-65.

Emerging Topics in Neuroscience of Traumatic Brain Injury: Brain Metabolism
1. Alessandri B, Rice AC, Levasseur J, DeFord M, Hamm RJ, Bullock MR. Cyclosporin A improves brain tissue oxygen consumption and learning/memory performance after lateral fluid percussion injury in rats. J Neurotrauma. 2002 Jul;19(7):829-41.

2. Bouma GJ, Muizelaar JP, Choi SC, Newlon PG, Young HF. (1991) Cerebral circulation and metabolism after severe traumatic brain injury: the elusive role of ischemia. J Neurosurg. 75(5):685---693.

3. Bergsneider M, Hovda DA, McArthur DL, Etchepare M, Huang SC, Sehati N, Satz P, Phelps ME, Becker DP. (2001) Metabolic recovery following human traumatic brain injury based on FDG-PET: time course and relationship to neurological disability. J Head Trauma Rehabil 16:135---148.

4. Charbel FT, Du X, Hoffman WE, Ausman JI. Brain tissue PO(2), PCO(2), and pH during cerebral vasospasm. Surg Neurol. 2000 Dec;54(6):432-7

5. Coles JP, Fryer TD, Smielewski P, Rice K, Clark JC, Pickard JD, Menon DK. (2004) Defining ischemic burden after traumatic brain injury using 15O PET imaging of cerebral physiology. J Cereb Blood Flow Metab. 24:191---201.

6. de Deyne C, Vandekerckhove T, Decruyenaere J, Colardyn F. (1996) Analysis of abnormal jugular bulb oxygen saturation data in patients with severe head injury.
Acta Neurochir (Wien). 138:1409---1415.

7. Diringer MN, Videen TO, Yundt K, Zazulia AR, Aiyagari V, Dacey RG Jr, Grubb RL, Powers WJ. (2002) Regional cerebrovascular and metabolic effects of hyperventilation after severe traumatic brain injury. J Neurosurg. 96:103---108.

8. Glenn, TC, Kelly, DF, Boscardin, WJ, McArthur, DL, Vespa, PM, Oertel, M, Hovda, DA, Bergsneider, M, Hillered, L, Martin, NA. . Energy dysfunction as a predictor of outcome after moderate or severe head injury: Indices of oxygen, glucose and lactate metabolism. J Cereb Blood Flow Metab 23:1239-1250, 2003.

9. Gopinath SP, Valadka AB, Uzura M, Robertson CS. Comparison of jugular venous oxygen saturation and brain tissue Po2 as monitors of cerebral ischemia after head injury.
Crit Care Med. 1999 Nov;27(11):2337-45.

10. Graham MM, Muzi M, Spence AM, O'Sullivan F, Lewellen TK, Link JM, Krohn KA. (2002) The FDG lumped constant in normal human brain. J Nucl Med 43:1157---1166.

11. Hattori N, Huang SC, Wu HM, Yeh E, Glenn TC, Vespa PM, McArthur D, Phelps ME, Hovda DA, Bergsneider M. Correlation of regional metabolic rates of glucose with glasgow coma scale after traumatic brain injury. J Nucl Med. 2003 Nov;44(11):1709-16.

12. Imberti R, Bellinzona G, Langer M. Cerebral tissue PO2 and SjvO2 changes during moderate hyperventilation in patients with severe traumatic brain injury.
J Neurosurg. 2002 Jan;96(1):97-102.

13. Kotapka MJ, Gennarelli TA, Graham DI, Adams JH, Thibault LE, Ross DT, Ford I. (1991) Selective vulnerability of hippocampal neurons in acceleration-induced experimental head injury. J Neurotrauma. 8:247---58.

14. Lifshitz J, Friberg H, Neumar RW, Raghupathi R, Welsh FA, Janmey P, Saatman KE, Wieloch T, Grady MS, McIntosh TK. Structural and functional damage sustained by mitochondria after traumatic brain injury in the rat: evidence for differentially sensitive populations in the cortex and hippocampus.

15. Magnoni S, Ghisoni L, Locatelli M, Caimi M, Colombo A, Valeriani V, Stocchetti N. Lack of improvement in cerebral metabolism after hyperoxia in severe head injury: a microdialysis study. J Neurosurg. 2003 May;98(5):952-8.

16. Meixensberger J, Jaeger M, Vath A, Dings J, Kunze E, Roosen K. Brain tissue oxygen guided treatment supplementing ICP/CPP therapy after traumatic brain injury.
J Neurol Neurosurg Psychiatry. 2003 Jun;74(6):760-4.

17. Menon DK, Coles JP, Gupta AK, Fryer TD, Smielewski P, Chatfield DA, Aigbirhio F, Skepper JN, Minhas PS, Hutchinson PJ, Carpenter TA, Clark JC, Pickard JD. Diffusion limited oxygen delivery following head injury. Crit Care Med. 2004 Jun;32(6):1384-90.

18. Menzel M, Doppenberg EM, Zauner A, Soukup J, Reinert MM, Bullock R. Increased inspired oxygen concentration as a factor in improved brain tissue oxygenation and tissue lactate levels after severe human head injury. Neurosurg. 1999 Jul;91(1):1-10.

19. Okonkwo DO, Povlishock JT.An intrathecal bolus of cyclosporin A before injury preserves mitochondrial integrity and attenuates axonal disruption in traumatic brain injury. J Cereb Blood Flow Metab. 1999 Apr;19(4):443-51.

20. Prins ML, Lee SM, Fujima LS, Hovda DA. Increased cerebral uptake and oxidation of exogenous betaHB improves ATP following traumatic brain injury in adult rats.
J Neurochem. 2004 Aug;90(3):666-72.

21. Reinert M, Barth A, Rothen HU, Schaller B, Takala J, Seiler RW. Effects of cerebral perfusion pressure and increased fraction of inspired oxygen on brain tissue oxygen, lactate and glucose in patients with severe head injury. Acta Neurochir (Wien). 2003 May;145(5):341-9

22. Riess P, Bareyre FM, Saatman KE, Cheney JA, Lifshitz J, Raghupathi R, Grady MS, Neugebauer E, McIntosh TK. Effects of chronic, post-injury Cyclosporin A administration on motor and sensorimotor function following severe, experimental traumatic brain injury. Restor Neurol Neurosci. 2001;18(1):1-8.

23. Rockswold SB, Rockswold GL, Vargo JM, Erickson CA, Sutton RL, Bergman TA, Biros MH. Effects of hyperbaric oxygenation therapy on cerebral metabolism and intracranial pressure in severely brain injured patients. J Neurosurg. 2001 Mar;94(3):403-11.

24. Valadka AB, Goodman JC, Gopinath SP, Uzura M, Robertson CS. Comparison of brain tissue oxygen tension to microdialysis-based measures of cerebral ischemia in fatally head-injured humans. J Neurotrauma. 1998 Jul;15(7):509-19

25. Vespa, P, McArthur, D, Glenn, T, O’Phelan, K, Etchepare, M, Kelly, D, Bergsneider, M, Martin, NA, Hovda, DA. J Neurotrauma. (2003) Persistently reduced levels of extracellular glucose early after traumatic brain injury correlate with poor outcome at six months: A microdialysis study. J Cereb Blood Flow Metab 23:865---877.

26. Vespa, P, McArthur, D, Alger, J, O’Phelan, K, Glenn, T, Bergsneider, B, Martin, NA, Hovda, DA. Regional Heterogeneity of Brain Metabolism using Cerebral Microdialysis: Concordance with Magnetic Resonance Spectroscopy and Positron Emission Tomography. Brain Pathology 2004 14:210-214.

27. Vigue B, Ract C, Benayed M, Zlotine N, Leblanc PE, Samii K, Bissonnette B. (1999) Early SjvO2 monitoring in patients with severe brain trauma. Intensive Care Med. 25(5):445---451.

28. Wu HM, Huang SC, Hattori N, Glenn TC, Vespa PM, Yu CL, Hovda DA, Phelps ME, Bergsneider M. Selective metabolic reduction in gray matter acutely following human traumatic brain injury. J Neurotrauma. 2004 Feb;21(2):149-61.

29. Jodicke A., Hubner F, Boker DK. Monitoring of brain tissue oxygenation during aneurysm surgery: prediction of procedure-related ischemic events. J Neurosurgery. 2004 Mar;98(3):515-23.

Respiratory Care of the Neurologic Patient
1. Menzel M, Doppenberg EMR, Zauneer A, et al. Increased inspired oxygen concentration as a factor in improved brain tissue oxygenation and tissue lactate levels after severe human head injury. J Neurosurg 1999; 91:1-10.

2. Muizelaar JP, Marmarou A, Ward JD, et al. Adverse effects of prolonged hyperventilation in patients with severe head injury: a randomized clinical trial. J Neurosurg 1991; 75:731-739.

3. Stocchetti N, Furlan A, Volta F. Hypoxemia and arterial hypotension at the accident scene in head injury. J Trauma 1996; 40:764-767.

4. Witchell RJ, Hoyt DB. Endotracheal intubation in the filed improves survival in patients with severe head injury. Arch Surg 1977; 132:592-597.

5. Chesnut RM. Avoidance of hypotension: conditio sine qua non of successful severe head-injury management. J Trauma 1997; 42:S4-S9.

6. Thurman D, Guerrero J. Trends in hospitalization associated with traumatic brain injury. JAMA 1999; 282:954-957.

7. Chesnut RM, Marshall LF, Klauber MR. The role of secondary brain injury in determining outcome from severe head injury. J Trauma 1993; 34:216-222.

8. Bronchard R, Albaladejo P, Brezac G, et al. Early onset pneumonia. Risk factors and consequences in head trauma patients. Anesthesiology 2004;100:234-239.

9. Leone M, Albanese J, Rousseau S, et al. Pulmonary contusion in severe head trauma patients. Chest 2003;124:2261-2266.

10. Valadka AB, Gopinath SP, Contant CF, Uzura M, Robertson CS. Relationship of brain tissue PO2 to outcome after severe head injury. Crit Care Med. 1998;26:1576-81.

14. Carmona Suazo JA, Maas AI, van den Brink WA, van Santbrink H, Steyerberg EW, Avezaat CJ. CO2 reactivity and brain oxygen pressure monitoring in severe head injury. Crit Care Med. 2000;28:3268-74.

15. Gracias VH, Guillamondegui OD, Stiefel MF, Wilensky EM, Bloom S, Gupta R, Pryor JP, Reilly PM, Leroux PD, Schwab CW. Cerebral cortical oxygenation: a pilot study. J Trauma. 2004;56:469-72.

16. van Santbrink H, Maas AI, Avezaat CJ. Continuous monitoring of partial pressure of brain tissue oxygen in patients with severe head injury. Neurosurgery. 1996;38:21-31.

17. Menzel M, Doppenberg EM, Zauner A, Soukup J, Reinert MM, Clausen T, Brockenbrough PB, Bullock R. Cerebral oxygenation in patients after severe head injury: monitoring and effects of arterial hyperoxia on cerebral blood flow, metabolism and intracranial pressure. J Neurosurg Anesthesiol. 1999;11:240-51.

1. 1. Institute of Medicine. (2003). “Health Professional Education: A Bridge to Quality”. The National Academies Press: Washington, D.C.

Outcomes of ICU Patients After Neurological Injury

1. Apgar V. A proposal for a new method of evaluation of the newborn infant. Anesth Analg 1953;32:260

2. Knaus WA, Zimmerman JE, Wagner DP, Draper EA, Lawrence DE. APACHE- acute physiology and chronic health evaluation: A physiologically-based classification system. Crit Care Med 1981;9:591-597

3. Teasdale G, Jennett B. Assessment of coma and impaired consciousness. A practical scale. Lancet 1974;2(7872):81-84

4. Jennett B, Bond M. Assessment of outcome after severe brain damage. Lancet 1975;1(7905):480-484

5. Mahoney FI, Barthel DW. Functional evaluation: The Barthel Index. Md State Med J 1965;14:61-65

6. Rankin J. Cerebral vascular accidents in patients over the age of 60. Scott Med J 1957;2:200-215

7. Ware JE, Sherbourne CD. The MOS 36-item short-form health survey (SF-36). Conceptual framework and item selection. Med Care 1992;30:473-483

8. Duncan PW, Wallace D, Lai SM, Johnson D, Embretson S, Laster LJ. The stroke impact scale version 2.0. Evaluation of reliability, validity and sensitivity to change. Stroke 1999;30:2131-2140

9. Diringer MN, Edwards DF. Admission to a neurologic/neurosurgical intensive care unit is associated with reduced mortality rate after intracerebral hemorrhage. Crit Care Med 2001;29:635-640

10. Mirski MA, Chang CWJ, Cowan R. Impact of a neuroscience intensive care unit on neurosurgical patient outcomes and cost of care. Evidence-based support for an intensivist-directed specialty ICU model of care. J Neurosurg Anesth 2001;13:83-92

11. Suarez JI, Zaidat OO, Suri MF, et al. Length of stay and mortality in neurocritically ill patients: impact of a specialized neurocritical care team. Crit Care Med 2004 (In Press)

12. Fanshawe M, Venkatesh B, Boots RJ. Outcome of stroke patients admitted to intensive care: experience from an Australian teaching hospital. Anesth Intensive Care 2002;30:628-632

13. Hilker R, Poetter C, Findeisen N, et al. Nosocomial pneumonia after acute stroke: implications for neurological intensive care medicine. Stroke 2003;34:975-981

14. Navarrete-Navarro P, Rivera-Fernandez R, Lopez-Mutuberia MT, et al. Outcome prediction in terms of functional disability and mortality at 1 year among ICU-admitted severe stroke patients: a prospective epidemiological study in the south of the European Union (Evascan Project, Andalusia, Spain). Intensive Care Med 2003;29:1237-1244

15. Diringer MN, Reaven NL, Funk SE, Uman GC. Elevated body temperature independently contributes to increased length of stray in neurologic intensive care unit patients. Crit Care Med 2004;32:1489-1495

16. Alvarez M, Nava JM, Rue M, Quintana S. Mortality prediction in head trauma patients: performance of Glasgow Coma Score and general severity systems. Crit Care Med 1998;26:142-148

17. Krumholz A, Berg AT. Further evidence that for status epilepticus “one size fits all” doesn’t fit. Neurology 2002;58:515-516

18. Shneker BF, Fountain NB. Assessment of acute morbidity and mortality in nonconvulsive status epilepticus. Neurology 2003;61:1066-1073

19. Claassen J, Lokin JK, Fitzsimmons B-FM, Mendelson FA, Mayer SA. Predictors of functional disability and mortality after status epilepticus. Neurology 2002;58:139-142